The U.S. Department of Energy (DOE) has announced 26 new science and technology challenges as part of the Genesis Mission, an initiative designed to advance innovation through artificial intelligence (AI). These challenges are intended to support DOE’s efforts in discovery science, energy, and national security.
According to DOE Under Secretary for Science and Genesis Mission Lead Dr. Darío Gil, “These challenges represent a bold step toward a future where science moves at the speed of imagination because of AI. It’s a game-changer for science, energy, and national security. By uniting the U.S. Government’s unparalleled data resources and DOE’s experimental facilities with cutting-edge AI, we can unlock discoveries that will power the economy, secure our energy future, and keep America at the forefront of global innovation.”
Assistant to the President and Director of The White House Office of Science and Technology Policy Michael Kratsios added, “President Trump’s Genesis Mission is mobilizing America’s unmatched scientific infrastructure and AI ingenuity to double the pace of discovery. These 26 challenges are a direct call to action to America’s researchers and innovators to join the Genesis Mission and deliver science and technology breakthroughs that will benefit the American people. We look forward to expanding the list of challenges across Federal agencies to bring even greater impact to the Mission.”
The announced challenges include using AI for faster power grid planning and improved reliability; digitizing decades of nuclear research for future decision-making; deploying AI in particle accelerators; designing materials with predictable functionality; modeling underground environments for energy development; automating laboratories for drug discovery; enhancing manufacturing productivity; accelerating quantum algorithm development; and advancing microelectronics.
Through partnerships with National Laboratories, industry, and academia, these efforts aim to provide measurable benefits such as more efficient energy systems, increased productivity in research and manufacturing, stronger supply chains, new job creation, advances in medicine, improvements in national security infrastructure, and support for technological leadership.
DOE Acting Under Secretary of Energy Alex Fitzsimmons stated: “AI has tremendous potential to amplify the Trump Administration’s mission to unleash American energy dominance. Thanks to Secretary Wright’s leadership, these Genesis Mission challenges will help DOE leverage AI-enabled tools to build a more affordable, reliable, and secure energy system for the American people.”
DOE Under Secretary for Nuclear Security Brandon Williams commented: “Under President Trump’s leadership, the Genesis Mission harnesses AI to strengthen America’s national security. By leveraging AI across our missions—from modernizing our nuclear deterrent to safeguarding critical infrastructure—we will ensure America remains at the forefront of global security and technological leadership. This commitment to applying cutting-edge science and technology protects our nation, marking a pivotal step towards a more secure, prosperous, and innovative future through collaborative federal efforts.”
This announcement comes as DOE continues its broader efforts in supporting clean energy transitions. For example,in July 2022, DOE introduced a $225 million program funded by President Biden’s Bipartisan Infrastructure Law aimed at implementing updated building energy codes nationwide.
In addition,DOE officials have highlighted before Congress how technology development through national laboratories aids environmental cleanup missions.
Other recent initiatives includea $96 million funding opportunity focused on decarbonizing transportation by expanding electric vehicle charging access,the use of innovative processes like passive energy techniques at cleanup sites,international engagement on clean energy transition, andsupporting over 140 programs under President Biden’s Justice40 Initiative to direct investments into disadvantaged communities.
For more information about the Genesis Mission or details on all 26 challenges set forth by DOE visit their official website.



